Destruxin B

Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochondrial pathway. Destruxin B through caspase-mediated apoptosis can significantly activate caspase-3 in vitro and in vivo, reducing the proliferation of tumor cells.

Catalog No. T11009Cas No. 2503-26-6

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Destruxin B

Catalog No. T11009Cas No. 2503-26-6

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Pack Size	Price	Availability	Quantity
1 mg	$1,180	35 days
5 mg	$4,450	35 days

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Product Introduction

Bioactivity

Description	Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochond
In vitro	Destruxin B (1-30 μM) inhibits cell proliferation by blocking mitochondrial caspase cascade activation in H1299 and A549 cells with IC50 values of 4.1 μM and 4.9 μM, respectively. In A549 cells, Destruxin B (1.25-20.00 μM; 48 hours) induces apoptotic cell death, increases promoter protein PUMA levels, and reduces Mcl-1 degradation resistance. Additionally, Destruxin B (10 or 20 μM; 72 hours) significantly reduces the survival ability of HT-29 human colorectal cancer cells in a time- and dose-dependent manner.
In vivo	Destruxin B (DB) (injection; 0.5-15 mg/kg/d for 6 weeks) reduces tumor growth in a time- and dose-dependent manner.

Chemical Properties

Molecular Weight	593.766
Formula	C₃₀H₅₁N₅O₇
Cas No.	2503-26-6

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Destruxin B